Alarmins from conjunctival fibroblasts up-regulate matrix metalloproteinases in corneal fibroblasts
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteinases-2 and -9 are secreted from human fibroblasts.
To investigate the pathophysiological role of fibroblasts in tissue metabolism, we analysed gelatin-degrading enzymes secreted from skin cells in culture. Using a gelatin-zymography method, matrix metalloproteinase (MMP)-2 was constitutively secreted from fibroblasts, whereas both MMP-2 and MMP-9 were secreted from keratinocytes. MMP-9 expression by fibroblasts was induced by the addition of tr...
متن کاملAnalysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy
PURPOSE To analyze for the presence of lipids in conjunctival fibroblasts of a patient with Schnyder corneal dystrophy (SCD). METHODS A proband with SCD was identified, and the pedigree was examined. The proband underwent an automated lamellar therapeutic keratoplasty (ALTK). At the same time, the proband underwent a skin and conjunctival biopsy. Specimens were sent for histological and ultra...
متن کاملGlucocorticoids regulate extracellular matrix metabolism in human vocal fold fibroblasts.
OBJECTIVES/HYPOTHESIS Given the recent emergence of encouraging efficacy data regarding the utility of intralesional glucocorticoid (GC) injection for a variety of vocal fold pathologies, we sought to describe the location and expression pattern of the GC receptors within the vocal folds and quantify the effects of GCs on vocal fold fibroblasts. STUDY DESIGN In vitro, in vivo. METHODS Immun...
متن کاملRed blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro.
Tissue remodeling is an important process in many inflammatory and fibrotic lung disorders. RBC may in these conditions interact with extracellular matrix (ECM). Fibroblasts can produce and secrete matrix components, matrix-degrading enzymes (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Imbalance in matrix synthesis/degradation may result in rearrangement of tissue architecture an...
متن کاملTGF-beta antisense oligonucleotides modulate expression of matrix metalloproteinases in isolated fibroblasts from radiated skin.
BACKGROUND Transforming growth factor-beta (TGF-beta) has been identified as an important component of wound healing. Recent developments in molecular therapy offer exciting prospects for the modulation of wound healing, specifically those targeting TGF-beta. The purpose of this study was to analyze the effect of TGF-beta targeting on the expression of matrix metalloproteinases (MMPs) in fibrob...
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ژورنال
عنوان ژورنال: International Journal of Ophthalmology
سال: 2020
ISSN: 2222-3959,2227-4898
DOI: 10.18240/ijo.2020.07.03